GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs6088813 | 1 | rs6141548 | chr20:33971085 | CPNE1 | chr20:34213968-34262539:- | 0.3 | 5.95 | 5.17E-9 | Height |
| THCA | cis | rs6088813 | 1 | rs6141548 | chr20:33971085 | GDF5 | chr20:33897002-34042568:- | -0.18 | -3.81 | 0.000154 | Height |
| THCA | cis | rs6088813 | 1 | rs6141548 | chr20:33971085 | UQCC | chr20:33890383-33999833:- | 0.32 | 10.23 | 2.48E-22 | Height |
| THCA | cis | rs6088813 | 1 | rs6141549 | chr20:33974051 | CEP250 | chr20:34042996-34099802:+ | -0.15 | -3.37 | 0.000804 | Height |
| THCA | cis | rs6088813 | 1 | rs6141549 | chr20:33974051 | CPNE1 | chr20:34213968-34262539:- | 0.3 | 5.95 | 5.17E-9 | Height |
| THCA | cis | rs6088813 | 1 | rs6141549 | chr20:33974051 | GDF5 | chr20:33897002-34042568:- | -0.18 | -3.81 | 0.000154 | Height |
| THCA | cis | rs6088813 | 1 | rs6141549 | chr20:33974051 | UQCC | chr20:33890383-33999833:- | 0.32 | 10.23 | 2.48E-22 | Height |
| THCA | cis | rs4959799 | 1 | rs61417737 | chr6:3291251 | PSMG4 | chr6:3259162-3268300:+ | -0.33 | -5.54 | 5.09E-8 | Survival in rectal cancer |
| THCA | cis | rs4911414 | 1 | rs6142102 | chr20:32704627 | RALY | chr20:32581732-32672675:+ | 0.15 | 4.49 | 9.06E-6 | Tanning;Skin sensitivity to sun;Red vs. non-red hair color;Freckles;Burning and freckling |
| THCA | cis | rs6988636 | 1 | rs61422480 | chr8:124188940 | FAM83A | chr8:124191287-124222317:+ | -0.33 | -4.38 | 1.46E-5 | Urinary uromodulin levels |
| THCA | cis | rs614226 | 1 | rs614226 | chr12:120974510 | COQ5 | chr12:120941083-120966964:- | -0.15 | -3.7 | 0.000236 | Type 1 diabetes nephropathy |
| THCA | cis | rs614226 | 1 | rs614226 | chr12:120974510 | POP5 | chr12:121016849-121019201:- | 0.16 | 4.95 | 1.02E-6 | Type 1 diabetes nephropathy |
| THCA | cis | rs614226 | 1 | rs614226 | chr12:120974510 | RNF10 | chr12:120972132-121015396:+ | -0.22 | -3.63 | 0.000313 | Type 1 diabetes nephropathy |
| THCA | cis | rs6088813 | 1 | rs6142358 | chr20:33960308 | CPNE1 | chr20:34213968-34262539:- | -0.31 | -6 | 3.94E-9 | Height |
| THCA | cis | rs6088813 | 1 | rs6142358 | chr20:33960308 | GDF5 | chr20:33897002-34042568:- | 0.17 | 3.64 | 0.000297 | Height |